PRP contains special cells called Platelets, that can cause growth of the hair follicles by theoretically stimulating the stem cells located in the Dermal Papilla as well as other structures of the hair follicle These special Platelet cells promotes healing, accelerates the rate and degree of tissue healing and regeneration, response of the body to injury, and formation of new cellular growth. The primary purpose of using PRP in hair restoration is to stimulate inactive or newly implanted hair follicles into an active growth phase.
Inside the Platelets are many intracellular structures such as glycogen, lysosomes and alpha granules. These granules within the PRP contain clotting and growth factors that are eventually released during the healing and repair process.
The process begins by taking a blood sample through an anticoagulated tube, with or without separating gel. The tubes are then centrifuged for approximately 5 minutes at 600 G (the speed and time will depend on the specific kit protocol). As a result of their density, the red cells sink in the tube, while at the upper part of the tube the plasma and platelets collect. PRP is usually referred to when a concentration of three-to-five-times normal standards has been collected. Once injected into the dermal layer, the platelets are activated; they inflate and growth factors are released. The most important growth factors in terms of PRP for hair application are:
PDGFs stimulate the growth of dermal mesenchyme. PDGF signals are involved in both epidermis follicle interaction and the dermal mesenchyme interaction required for hair canal formation and the growth of dermal mesenchyme, respectively 5 VEGF belongs to a family of powerful growth factors with action on mitotic cells and the endothelial cells of blood vessels, and increases vascular permeability. The hair follicle is an avascular structure, the growth of which depends on the vessels and capillaries that form the vascular plexus in the dermal papilla. Yano et al6 identified VEGF as a significant mediator of hair follicle growth and cycling, providing the first direct evidence that improved follicle vascularisation promotes hair growth, as well as increasing follicle and hair size.
Sign up now for more information about our company